Absence of E-cyclins E1 and E2 affects cell cycle progression, fibrogenesis and tumorgenesis in the murine liver

Recent studies revealed that cyclin E1 and E2 are dispensable for continuously dividing cells, but are important for endoreplication and essential for cell cycle re-entry of quiescent fibroblasts. The aim of this study was to explore the role of E-type cyclins during liver regeneration and to study the influence of cyclin E depletion on fibrogenesis and HCC development in murine c-myc tumor models. For our studies on liver regeneration we performed 70% partial hepatectomy (PH) in cyclin E1 and E2 knockout mice (KO) and wildtype (WT) controls. For studies on fibrogenesis and tumorgenesis, hepatocyte-specific c-my…