Full breadth analysis of AFP-specific CD8+ T cells in patients with hepatocellular carcinoma in the blood and in the liver
MC Neagu, T Boettler, N Kersting, N Kersting, C Neumann-Haefelin, HE Blum, R Thimme, HC Spangenberg · Zeitschrift für Gastroenterologie · 2008 · Heft 01
Bibliografische Angaben
Zusammenfassung
The aim of this study was to analyze the vigour and breadth of AFP T cell responses in patients with hepatocellular carcinoma (HCC) and chronic HCV infection. In order to determine the CD8+ T cell responses in the context of diverse HLA class I alleles, we performed a comprehensive analysis by using a panel of overlapping peptides spanning the whole alpha-fetoprotein and analyzed the peripheral blood mononuclear cells (PBMCs) and intrahepatic lymphocytes from a cohort of 14 patients with chronic hepatitis C Virus (HCV) infection and 41 patients suffering from HCC and the PBMCs of 10 healthy donors by an enzyme-l…
