EXPERIENCE WITH CONTINUOUS TERLIPRESSIN INFUSION IN PATIENTS WITH HEPATORENAL SYNDROME

Several studies reported improvement of renal function by bolus injections of terlipressin (TER) in patients with hepatorenal syndrome (HRS). The magnitude of this effect as well as an improvement of survival are controversially discussed. Furthermore, treatment is limited by serious adverse events such as intestinal ischemia or arrhythmias. Recently, in endotoxemia, advantages of continuous versus bolus infusion of TER has been reported. Thus, aim of this study was to analyze the effect of continuous TER infusion. Patients and Methods: 32 patients with cirrhosis, ascites and hepatorenal syndrome were treated wi…