Desynchronisation of neuronal network activity in traumatic brain injury

Traumatic brain injury (TBI) is the main cause for mortality and long-time disability in young adults. Apart from structural lesions release of neuroactive substances has been considered to cause functional neuronal disturbances. The composition of cerebrospinal fluid (CSF) from patients with TBI is often modified, but the functional impact of this modified CSF is still not fully investigated. We therefor tested the functional impact of physiologic and modified CSF on the electrophysiological parameters of neuronal networks. Cryopreserved embryonic rat cortex neurons were thawed and plated on multielectrode arra…