Minocycline has acute inhibitory effects on human motor cortex excitability

Objective: Minocycline has efficacy to alleviate disease in several animal models of neurological disorders, among other mechanisms by decreasing glutamate excitotoxicity. To explore acute effects of minocycline on human motor cortex excitability we used transcranial magnetic stimulation (TMS). Methods: A single oral dose of 200mg minocycline was administered in 12 healthy subjects in a randomized, double-blind, placebo-controlled crossover design 4 hours before several measures of motor cortex excitability were tested with single- and paired-pulse TMS. Results: Mean cortical silent period, an inhibitory paramet…