Functional properties of posterior hypothalamic neurones – experience from microelectrode recordings in patients with Cluster headache

Introduction: Recently, deep brain stimulation (DBS) of the posterior hypothalamus has been shown to be effective in the treatment of drug-resistant chronic cluster headache. Objective: To study the functional properties of neurones of the posterior hypothalamus with regard to the nociceptive relay function and with regard to the pathophysiology of cluster headache. Methods: Patients fulfilled the published criteria for DBS in chronic cluster headaches. Electrodes were implanted stereotactically in the ipsilateral posterior hypothalamus according to the published coordinates (2mm lateral, 3mm posterior, 5mm infe…