RD-1 selected peptides for the immunodiagnosis of active tuberculosis
D Goletti, S Carranza, C Lange, F Mengoni, C Mastroianni, D Cirillo, R Markova, R Drenska, M Amicosante, J Domínguez Benitez, C Saltini, E Giradi · Pneumologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Introduction: There is a clear need for new tools in the diagnosis of active tuberculosis (TB), especially for cases in which microbiological diagnosis is difficult to accomplish such as extra-pulmonary and smear-negative TB. We set-up an IFN-gamma assay based on RD1 selected peptides, associated to active TB, differently from those based on RD1 overlapping peptides (QuantiFERON-TB Gold and T-SPOT.TB.) designed to identify TB infection. Objectives of this study are to evaluate the performance of our assay: 1) on subjects with suspected active TB enrolled in six european hospitals; 2) in comparison with commercia…
