Nationwide Study on Moxifloxacin susceptibility among pneumococcal isolates from invasive disease in Germany

Background: In the last two decades, the worldwide increase in antibiotioc resistance in Streptococcus pneumoniae has developed into a serious problem. Method: In this study 679 Streptococcus pneumoniae isolates, collected in Germany in the year 2006 were examined. Minimal inhibitory concentration (MIC) testing was performed using the broth microdilution method as recommended by the Clinical Laboratory Standards Institute. The pneumococcal strains were isolated from blood (n=568, 83,7%), Cerebrospinal fluid (CSF; n=86; 12,7%), broncho-alveolar lavage (n=12; 1,8%) und pleural fluid (n=13; 1,9%). Results: MIC-valu…