Inflammatory response of a subset of IL-17 and IL-22-producing CD4+ T cells in human Mtb-infection
B Kalsdorf, M Ernst, R Wilkinson, J Hofmeister, S Ross, D Abrahams, F Isaacs, G Black, H Hassan, G Walzl, W Hanekom, C Lange, T Scriba · Pneumologie · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Background: IL-17 was recently described to be protective in mice immune response to Mycobacterium tuberculosis (Mtb). IL-22 mediates chronic T-cell inflammation. Little is known about the role of these cytokines in human tuberculosis (TB) infection. To investigate whether IL-17 and IL-22 contribute to the human anti-mycobacterial immune response we examined immune responses from blood and bronchoalveolar lavage (BAL) cells of healthy volunteers and patients with culture confirmed pulmonary TB. Methods: Peripheral mononuclear (PBMC) cells from healthy adults with or without latent Mtb-infection were stimulated w…
