Inhibition of Glyoxalase 1 impairs physiological wound healing
TH Fleming, S Stoyanov, TM Theilen, U Zeuge, PJ Thornalley, P Humpert, M Brownlee, PP Nawroth, A Bierhaus · Diabetologie und Stoffwechsel · 2008 · Heft 04
Bibliografische Angaben
Zusammenfassung
Increased formation of the reactive dicarbonyl compound, methylglyoxal (MG), in vivo has been shown to be associated with the onset of microvascular disease and impaired wound healing. MG and other endogenously formed dicarbonyl compounds can react with proteins to form Advanced Glycation Endproducts (AGEs). Glyoxalase I (GLO1) is part of the glyoxalase system, and is the major cellular defence in the detoxification of MG. Decreased GLO1 activity in situ has been shown to result in an accumulation of MG, increased AGE formation and tissue damage. As to determine the role that MG and GLO1 may play in the cellular…
