Adipose tissue PGC1 alpha and PGC1 beta mRNA expression in visceral obesity and in response to exercise training

Aims: The PPARgamma co-activators 1 (PGC1) are major transcriptional regulators of several crucial aspects of oxidative metabolism, including mitochondrial biogenesis and respiration. We examined whether PGC1 alpha and/or PGC1 beta mRNA expression in human adipose tissue is fat-depot specific. We also studied whether their expression in adipose tissue is associated with metabolic parameters and whether their expression is regulated by intensive physical exercise. Research design and methods: We determined metabolic parameters and measured PGC1 alpha and PGC1 beta mRNA expression using quantitative real-time PCR…