Visfatin is a positive regulator of MCP-1 in human mesenchymal stem cell-derived adipocytes

Visfatin has recently been characterized as a novel insulin-mimetic and proinflammatory adipokine. However, potential mediators of the proinflammatory effects of this adipokine in fat cells have not been studied. In the current study, the impact of visfatin on expression of the proinflammatory and proatherogenic protein monocyte chemoattractant protein (MCP)-1 was determined in fully differentiated human mesenchymal stem cell-derived adipocytes. Interestingly, protein secretion and mRNA production of MCP-1 were induced significantly after visfatin stimulation. Thus, visfatin induced MCP-1 secretion almost 2-fold…