Effect of systemic administration of GCSF/SCF or FL on hypoxic/hyperoxic ischemic brain injury in newborn mice

Background: Hypoxic ischemic (HI) injury is a major cause in the pathogenesis of periventricular leukomalacia in preterm infants, resulting in cognitive deficits and and motor disabilities. We have recently shown that the administration of granulocyte colony stimulating factor (G-CSF) and stem cell factor (SCF) increases excitotoxic brain injury in newborn mice, when administered in the acute phase of the insult. When administered after the acute phase of injury, GCSF/SCF significantly reduces excitotoxic injury. However our results obtained in the excitotoxic brain injury model are controversial to published re…