ATM and p53 are potential mediators of Chloroquine-induced resistance to mammary carcinogenesis

Fragestellung: The use of agents to prevent the onset of and/or the progression to breast cancer has the potential to lower breast cancer risk. B. W. O'Malley et al. have previously shown that the tumor suppressor gene p53 is a potential mediator of hormone (estrogen/progesterone (E/P)) -induced protection against chemical carcinogen-induced mammary carcinogenesis in animal models. Here we demonstrate for the first time a breast cancer protective effect of Chloroquine (CQ) in an animal model. Methodik: Cell Culture, Short Interfering RNA Transfection, Western Blot Analysis, Flow Cytometry, Animal Model. Ergebnis…