Attenuation of lipotoxicity by liver regeneration protein ALR

Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic pathology, ranging from steatosis to cirrhosis with nonalcoholic steatohepatitis (NASH) on an intermediate level. The aim of our study was to investigate the potential role of liver regeneration factors such as ALR (augmenter of liver regeneration) in NASH. ALR, a protein known to have a beneficial impact on liver regeneration was analyzed for its potential protective role under conditions of NASH in vitro and in vivo. A mouse model for NASH was used to analyze ALR mRNA expression by quantitative RT-PCR revealing elevated ALR levels in mice fed…