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Caveolin-1 upregulation during hepatocyte transdifferentiation alters the TGF-beta response

C Meyer, Y Liu, J Dzieran, I Ilkavets, S Dooley · Zeitschrift für Gastroenterologie · 2010 · Heft 01

Dokument
816686
CareLit-ID
Jahr
2010
Publikation
PDF
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Metadaten
DOI
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Bibliografische Angaben

Zeitschrift
Zeitschrift für Gastroenterologie
Autor:innen
C Meyer, Y Liu, J Dzieran, I Ilkavets, S Dooley
Ausgabe
Heft 01 / 2010
Seiten
–
Erschienen: 2010-01-12 00:00:00
ISSN
0044-2771
DOI
10.1055/s-0029-1246360

Zusammenfassung

Active TGF-beta receptors are internalized from the plasma membrane by two distinct endocytic routes. The clathrin dependent internalization route is considered to increase TGF-beta mediated Smad signaling, whereas the Caveolin-1 dependent endocytic route leads to receptor degradation and thus dampening of signaling. Noteworthy, recent work established Caveolin-1 as an active participant in TGF-beta signaling as connective tissue growth factor (CTGF) expression is regulated by Smad3 and Caveolin-1. During culture on collagen coated plates, hepatocytes transdifferentiate, thereby losing polarity and tight junctio…

Schlagworte

Caveolin-1 EMT Signaling TGF-beta hepatocytes Zeitschrift für Gastroenterologie