miR-198 acts as novel tumorsuppressor miRNA in hepatocellular carcinoma
N Elfimova, A Noetel, S Schievenbusch, M Kwiecinski, H Varnholt, F Schulze, M Quasdorff, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aims: Hepatocellular carcinoma (HCC) has a rising incidence in western countries despite advanced antiviral therapeutic modalities. Various molecular alterations occur in preneoplastic nodules and escalate in HCCs, including dysregulation of well-known molecular pathways. The important role of microRNAs in those pathways has recently been emphasized. miRNA are small noncoding RNAs inhibiting gene expression by interaction with the untranslated region (3´-UTR) of mRNAs. By previous miRNA-profiling, we identified miR-198 as a downregulated miRNA during hepatocarcinogenesis. In the present approach we now address t…
