Exploring the diversity of ways to overcome TRAIL resistance in HCC: contribution of survival signaling, chemotherapeutical drugs and antiapoptotic BCL-2 proteins
BC Köhler, T Urbanik, B Vick, RJ Boger, S Heeger, PR Galle, M Schuchmann, H Schulze-Bergkamen · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Aim: In this study we analysed ways to overcome resistance of hepatocellular carcinoma (HCC) cells towards apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). In particular, the effect of treatment with recombinant TRAIL or agonistic TRAIL antibodies in combination with chemotherapeutic drugs, specific kinase inhibitors as well as the commitment of antiapoptotic BCL-2 proteins was investigated. Methods: Surface expression of TRAIL receptors (TRAIL-R1–4) and expression levels of the antiapoptotic BCL-2 proteins MCL-1 and BCL-xL were analysed by flow cytometry and Western blot, re…
