Decreased expression of microRNA-125b may contribute to the pathogenesis of hepatocellular carcinoma
M Quasdorff, N Elfimova, I Strack, A Noetel, D Nierhoff, T Goeser, U Protzer, HP Dienes, M Odenthal · Zeitschrift für Gastroenterologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Introduction: . microRNA (miR), that posttranscriptionally regulate expression of numerous cellular genes by targeting mRNA, play an important role in cell proliferation and differentiation. Dysregulation of miRNA expression, particularly of miR-125b, was shown to be involved in carcinogenesis. We here focused on the expression and putative pathogenic role of miR-125b in development of hepatocellular carcinoma (HCC). Methods: We studied expression of miR-125b in human hepatoma cell lines and at different stages of tumorigenesis in livers of Alb-SV40 T-Ag inducible transgenic mice triggered by injection of Cre-ex…
