Transforming Growth Factor Beta (TGFβ) Gene Polymorphisms in Different Phenotypes of Sarcoidosis
S Pabst, T Fränken, J Schönau, I Beier, M Lennarz, S Stier, D Skowasch, G Nickenig, R Meyer, C Grohé · Pneumologie · 2010 · Heft 01
Bibliografische Angaben
Zusammenfassung
Background: The etiology of sarcoidosis is unclear. Single nucleotide polymorphisms (SNPs) in transforming growth factor beta (TGFβ)-2 and -3 were reported to be associated with the development of lung fibrosis in patients with sarcoidosis. Methods: One SNP in TGFβ-2 (rs1891467) and one SNP in TGFβ-3 (rs3917200) which were reported to be associated with lung fibrosis in sarcoidosis patients were investigated by real-time-polymerase chain reaction (PCR). 296 patients with sarcoidosis (acute/self remitting=70, chronic n=168, acute/chronic=58, fibrosis n=34) were investigated. The genotype frequencies were compared…
