CareLit Fachartikel
Anti-Gliadin Antibodies Direct Gliadin Transport in Enterocytes towards Tolerance Induction
N Lübbing, S Rudloff, I Panzer, MV Barone, S Auricchio, KP Zimmer · Klinische Pädiatrie · 2010 · Heft 03
Dokument
816899
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Introduction: Gliadin is known to be the responsible antigen for Celiac Disease (CD). Anti-gliadin antibodies, which are present in human milk, may explain the protective effect of breastfeeding. The delivery of gliadin peptides (GP) to HLA-DR positive late endosomes (LE) of enterocytes is required for antigen presentation and generation of oral tolerance towards GP. Methods: The aim of this study was to examine, whether gliadin-specific antibodies are able to direct GP to LE of enterocytes. We incubated duodenal biopsies of CD- and control-patients with GP and serum of CD-patients. In addition, we incubated Cac…
Schlagworte
Antibodies
Celiac Disease
IgA
late endosomes
oral tolerance
toxic peptides
Klinische Pädiatrie
