CareLit Fachartikel

Activation of WNT/β-catenin signaling attenuates experimental emphysema

M Königshoff, N Kneidinger, A Yildirim, R Dumitrascu, R Schermuly, O Eickelberg · Pneumologie · 2010 · Heft 03

Dokument
816905
CareLit-ID
Jahr
2010
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig

Bibliografische Angaben

Zeitschrift
Pneumologie
Autor:innen
M Königshoff, N Kneidinger, A Yildirim, R Dumitrascu, R Schermuly, O Eickelberg
Ausgabe
Heft 03 / 2010
Seiten
–
Erschienen: 2010-03-01 00:00:00
ISSN
0934-8387
DOI
10.1055/s-0030-1251100

Zusammenfassung

Rationale : Chronic obstructive pulmonary disease is a devastating and poorly understood disease. Currently, no causal therapy for COPD is available. Objectives : To elucidate the impact of WNT/β-catenin signaling in human COPD and its potential role as a preventive and therapeutic target in experimental emphysema. Methods : The expression, localization and activity of WNT/β-catenin signaling were assessed in 12 human COPD and 12 transplant donor samples using quantitative RT-PCR, immunohistochemistry, and western blotting. The role of WNT/β-catenin signaling and therapeutic modulation thereof in vivo was assess…

Schlagworte

Pneumologie