Population structure of Pseudomonas aeruginosa in CF and COPD

Chronic airway infections with Pseudomonas aeruginosa are common in individuals with bronchiectasis or cystic fibrosis (CF). P. aeruginosa can also be isolated from the sputum of adults with chronic obstructive pulmonary disease (COPD), but the role of the organism in the course of the disease is less well characterized than in other clinical settings. The population genetics of P. aeruginosa in these diseases and in acute infections was investigated by a microarray analysis representing the core genome by single nucleotide polymorphisms and the accessory genome by markers of genomic islets and islands, yielding…