IL28B polymorphism is associated with acute presentation and spontaneous clearance in hepatitis C virus infection
S Beinhardt, M Strasser, M Gschwantler, R Stauber, M Bischof, M Imre, A Maieron, H Laferl, K Rutter, AF Stättermayer, TM Scherzer, P Steindl-Munda, H Holzmann, P Ferenci, H Hofer · Zeitschrift für Gastroenterologie · 2010 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Antiviral therapy with pegylated interferon is highly effective in patients with acute hepatitis C. However, a substantial proportion of patients clear the virus spontaneously without treatment. Recently, a genetic polymorphism occurring in the interferon-lambda gene region (IL28B-SNP, rs12979860), encoding a type III interferon was shown to influence outcome of hepatitis C virus infection. Aim of the present study was to compare the prevalence of rs12979860 in patients with acute hepatitis C (AHC), chronic HCV infection and healthy controls. In addition, the impact of rs12979860 on spontaneous clear…
