Early prediction for the success of the antiviral therapy by using HOMA index in chronic hepatitis C patients

Background: The response to pegylated interferon (PEG-IFN) and ribavirin (RBV) treatment in chronic hepatitis C (CHC) is influenced by numerous factors. High baseline HOMA index, viral or metabolic insulin resistance (IR) or type 2 diabetes mellitus, hepatic steatosis and abnormal ALT on week 12 are associated with poor results. Aim: To analyze the association between these parameters and the success of the antiviral treatment. Patients and Methods: 116, treatment naïve CHC patients (46 male, M/70 female, F; all pts. genotype 1) were involved into the study. The mean age 47.6±4.7 (18–65) years, mean body weight…