Vaccination against Helicobacter pylori with gamma-glutamyltranspeptidase

Helicobacter pylori (H.p.) is the most widespread bacterial infection, affecting half of the worlds population and causing peptic ulcers and gastric cancer. Although big efforts have been initiated to develop a vaccine against this pathogen none of these experimental approaches led to successful results in human studies and thus failed to generate an approved vaccine in humans. It is unclear if this is due to the antigens used, the vaccine formulations tested to induce protective immunity or the laboratory infection models applied. Our group described a virulence factor of H. pylori, the H.p. gamma-glutmyltransp…