Contribution of E-type cyclins to hepatic fibrosis in human and mice

Recent studies demonstrated that the E-type cyclins E1 (CcnE1) and E2 (CcnE2) are not essential for cell proliferation per se, but for transition of quiescent cells into the cell cycle. We recently showed that CcnE1 is a key player for hepatocyte proliferation during liver regeneration, while CcnE2 is a negative regulator of CcnE1. The aim of this study was to investigate the potential contribution of CcnE1 for liver fibrosis in human and mice. Increase of CcnE1 expression in hepatocytes and non-parenchymal cells in human fibrotic livers hinted at an important role of CcnE1 in liver fibrosis. Accordingly, admini…