Confocal laser endomicroscopy detects hypervascularization as an activity pararameter in patients with ulcerative colitis

Introduction: Increased vascular permeability and angiogenesis have been suggested as integral parts in the pathogenesis of ulcerative colitis (UC). Recently, confocal laser endomicroscopy (CLE) was introduced, allowing in vivo microscopic imaging within the mucosal layer of the gut at a subcellular resolution. Aim: To investigate the utility of CLE in predicting hypervascularization in patients with UC. Material & methods: Consecutive patients with UC underwent total colonoscopy and were examined with CLE (ColoFlexUHD, Mauna Kea Technologies, Paris, France). Therefore, 5ml 10% fluorescein was administered intra…