The effect of bile acids on human pancreatic duct cells
I Ignáth, P Hegyi, C Székely, M Hasewaga, M Inoue, E Alton, U Griesenbach, T Takács, J Lonovics, A Varró, B Argent, M Gray, Z Rakonczay Jr · Zeitschrift für Gastroenterologie · 2008 · Heft 05
Bibliografische Angaben
Zusammenfassung
We have previously shown that exposure of intact guinea pig pancreatic ducts to bile acids, which may occur e.g. in acute pancreatitis, induces intracellular acidification and a marked increase in intracellular Ca2+ concentration ([Ca2+]i). Moreover, a low dose of chenodeoxycholate (CDC) stimulates the luminal anion exchanger which suggests a possible role of cystic fibrosis transmembrane conductance regulator (CFTR) in this effect. There are no available data concerning the effect of bile acids on human pancreatic duct cells. The aim of our study was to examine the effects of CDC or glycochenodeoxycholate (GCDC…
