Intrauterin use of hyperconcentrated platelet concentrates collected with Trima Accel in a case of neonatal alloimmune thrombocytopenia

Aims: Due to the threat of serious or fatal bleedings fetuses with neonatal alloimmune thrombocytopenia (NAIT) may need intrauterine PLT transfusions. To prevent a volume overload or a AB0 minor incompatibility, standard PLT concentrates need to be washed to increase the PLT concentration and to reduce the plasma content. Hyperconcentrated single donor platelet concentrates (HCPs) are a therapeutic alternative. We report the first case of NAIT successfully treated with HCPs collected with the Trima AccelTM (TA). Case report: A 31-year-old woman with a history of NAIT in the preceding pregnancy underwent cordocen…