Ingestion of capsaicin capsules induces symptoms in patients with non ulcer dyspepsia: Chemical hypersensitivity or hypervigilance?

Introduction: The ingestion of capsules containing capsaicin, the pungent ingredient of chili pepper, induces more intense upper GI sensations in patients with non ulcer dyspepsia (NUD) than in health, in patients with inflammatory bowel disease (IBD), peptic ulcer disease (PUD), and other GI disorders. Whether this is due to chemical hypersensitivity or hypervigilance is yet not clear. Aims: 1) to further evaluate whether oral ingestion of capsaicin containing capsules ('capsaicin test') induces more symptoms in patients with NUD than in health and in patients with upper GI symptoms of other origin. 2) to deter…