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Markers of oxidative stress and risk of type 2 diabetes mellitus: Results from the MONICA/KORA Augsburg Study 1984–2002

B Thorand, A Zierer, J Baumert, M Karakas, C Meisinger, A Peters, C Herder, W Koenig · Das Gesundheitswesen · 2010 · Heft 09

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Jahr
2010
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Bibliografische Angaben

Zeitschrift
Das Gesundheitswesen
Autor:innen
B Thorand, A Zierer, J Baumert, M Karakas, C Meisinger, A Peters, C Herder, W Koenig
Ausgabe
Heft 09 / 2010
Seiten
–
Erschienen: 2010-09-02 00:00:00
ISSN
0941-3790
DOI
10.1055/s-0030-1266360

Zusammenfassung

Background: We sought to elucidate the role of oxidative stress in the development of incident type 2 diabetes by measuring oxidized LDL (ox-LDL) and myeloperoxidase (MPO) in a large cohort study. Methods: Using a case-cohort design, serum levels of ox-LDL and MPO were measured in 460 cases with incident type 2 diabetes and 1,474 non-cases selected from a source population of 7,936 middle-aged men and women who participated in the population-based MONICA/KORA Augsburg studies between 1984–1995. The mean follow-up time was 10.9±4.7 years. Results: After adjustment for age, survey, and lifestyle factors, elevated…

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Das Gesundheitswesen