Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 (Lp-PLA2) mass and activity: Meta-analysis of genome-wide association studies from five com…
J Baumert, J Bis, A Dehghan, M Barbalic, H Grallert, C Lu, R Schnabel, K Rice, J Witteman, R Tracy, W Koenig, E Benjamin, C Ballantyne · Das Gesundheitswesen · 2010 · Heft 09
Bibliografische Angaben
Zusammenfassung
Background: Heritability of lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme that generates pro-inflammatory and pro-atherogenic compounds in the arterial vascular wall and which may represent a therapeutic target in coronary heart disease (CHD), is incompletely understood. Methods: We sought to investigate genetic loci related to Lp-PLA2 mass or activity by conducting meta-analyses of genome-wide association (GWA) findings from five population-based studies as part of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, comprising 13,664 subjects. Results: In meta-an…
