Early diagnosis of Alzheimer's disease using cortical thickness: impact of cognitive reserve
O Querbes, F Aubry, J Pariente, JA Lotterie, JF Demonet, V Duret, M Puel, I Berry, JC Fort, P Celsis · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · 2010 · Heft 11
Bibliografische Angaben
Zusammenfassung
Purpose: Cerebral atrophy measured by Magnetic Resonance structural Imaging has been proposed as a surrogate marker to improve the early diagnosis of Alzheimer's Disease (AD). More precisely, it could be a useful tool to distinguish Mild Cognitive Impairment (MCI) subjects who will effectively convert to AD from those who will remain at the MCI stage. However, studies on large samples are still required to determine cerebral atrophy's practical interest at the individual level, especially with regards to its capacity to disentangle the confounding role of cognitive reserve. Materials and Methods: One hundred and…
