CareLit Fachartikel
Expression of the multiligand receptor megalin in liver
U Pieper-Fürst, R Hall, T Sauerbruch, F Lammert · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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819270
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Jahr
2011
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Zusammenfassung
Confocal microscopy has indicated that hepatic stellate cells (HSCs) might express megalin [1]. Since megalin is the receptor of the retinol-retinol binding protein-complex in kidney and is responsible for the resorption of vitamin A and other metabolites from urine [2], we assumed participation of this endocytotic multiligand receptor in the retinol storage system of HSCs. Based on the observation that HSCs lose their ability to store retinol during fibrogenesis, we compared megalin expression in healthy and fibrotic livers after CCl4 challenge. A megalin-specific rabbit antiserum was generated by immunizing ra…
Schlagworte
Centrilobular areas
Fibrogenesis
GP330
LRP2
Megalin
Non-parenchymal cells
Zeitschrift für Gastroenterologie
