CareLit Fachartikel
The proliverative role of WISP1 in hepatocellular carcinoma
S Lukowski, H Weng, S Dooley, I Ilkavets · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Dokument
819278
CareLit-ID
Jahr
2011
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Hepatocellular carcinoma (HCC) is the most common primary malignant tumor of the liver and one of the most common cancer related death. With few treatment options and poor prognosis, HCC poses a major health problem worldwide. In our study we discovered WISP1 as a new marker of HCC. Our data show that WISP1 is highly overexpressed in hepatocellular carcinoma (HCC) patient samples in comparison to healthy patients (2 individuals were tested). WISP1 expression and secretion in HCC cell lines (HLF, FLC4, Huh7) is also strongly increased, time and density dependent. To investigate WISP1 function in hepatocarcinogene…
Schlagworte
HCC cell lines
RNAi
Wisp1
hepatocellular carcinoma
proliferation
Zeitschrift für Gastroenterologie
