CareLit Fachartikel
Expression of the organic anion transporters OATP1B1, OATP1B3, and OATP2B1 in human liver is affected by genetic and nongenetic factors
A Nies · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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819279
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Jahr
2011
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Zusammenfassung
Transport proteins in the sinusoidal membrane of hepatocytes mediate drug uptake, which is required for hepatic drug metabolism and elimination. Anionic drugs (e.g. statins, methotrexate, digoxin, paclitaxel) may be taken up into the hepatocytes by members of the organic anion transporting polypeptide (OATP) family, i.e. OATP1B1 (gene symbol SLCO1B1), OATP1B3 (SLCO1B3), and OATP2B1 (SLCO2B1) [1]. As interindividual variability of hepatic OATP expression may affect drug response, we systematically investigated genetic and nongenetic factors of OATP expression. Methods: Liver tissue samples from 150 Caucasians tog…
Schlagworte
MALDI-TOF MS
OATP protein
Organic anion transporter
SLCO gene
pharmacogenomics
Zeitschrift für Gastroenterologie
