CareLit Fachartikel
Expression of Transferrin, Transferrin Receptor2 and Hephaestin genes in the models of liver injury
N Sheikh, N Naz, IA Malik, G Ramadori · Zeitschrift für Gastroenterologie · 2011 · Heft 01
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819281
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Jahr
2011
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Zusammenfassung
Iron is vital for almost every organism by participating in a wide variety of metabolic processes and its tight regulation is an important aspect of life of the cell. Tf, TfR2 and hephaestin are the genes involved in the transport and metabolism of body iron. We used different rat models to observe the hepatic changes in the expression of these genes by damaging noxae: CCl4 administration and Partial hepatectomy (PH). Total liver RNA was isolated, reverse transcribed and studied by real time PCR. Tf expression was downregulated to 0.44 fold (24h; P=0.004**), TfR2 to 0.52 fold (12h; P=0.137) and Heph to 0.43 fold…
Schlagworte
CCl4
Heph
PH
Tf
TfR2
Zeitschrift für Gastroenterologie
