A novel memory function of tolerant CD8+ T cells in anti-microbial immunity
J Böttcher, S Hegenbarth, D Stabenow, DH Busch, P van Endert, W Kolanus, C Kurts, JL Schultze, L Diehl, PA Knolle · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
Antigen-experienced memory T cells are defined by longevity and stem cell-like plasticity enabling them to give rise to effector T cells fighting microbial infection. It is believed that they arise from various stages of immunogenic T cell differentiation. Here, we provide evidence for a novel CD8+ T cell population (TL cells) that has memory function, but is generated under non-inflammatory conditions by antigen-presenting liver sinusoidal endothelial cells (LSEC) in vitro and in vivo. After efficient cross-presentation of soluble and gut-derived antigens by LSEC to naïve CD8+ T cells, antigen–experienced TL ce…
