The frequencies of Foxp3+ regulatory T cells in livers and peripheral blood of type I autoimmune hepatitis patients correlate with inflammatory activity
M Peiseler, M Sebode, B Franke, F Wortmann, A Quaas, D Schwinge, C Weiler-Normann, AW Lohse, C Schramm, J Herkel · Zeitschrift für Gastroenterologie · 2011 · Heft 01
Bibliografische Angaben
Zusammenfassung
The pathogenesis of autoimmune hepatitis (AIH) is not clear. In pediatric patients with type II AIH, a reduced frequency and function of CD4+CD25+Foxp3+ regulatory T cells (Treg) has been reported (1). However, the role of Treg in type I AIH is unclear. Here we analysed the percentage of Treg in the peripheral blood of 26 type I AIH patients, of whom 11 were analysed at diagnosis before treatment initiation, and of 19 healthy donors. To restrict analysis to define Treg and not activated CD4+ T cells, we counted only CD4+CD25highCD127lowFoxp3+ cells as Treg. We found that Treg frequency did not significantly diff…
