Function of myeloid NFkB in cigarette smoke induced lung carcinoma proliferation

Objective: From clinical investigation it is known that the presence of COPD significantly increases the risk of developing lung cancer. COPD-specific inflammation likely increases the speed of tumor growth. To investigate the function of myeloid NFκB in cigarette smoke (CS) induced lung tumor proliferation. Methods: 5×105 Lewis lung carcinoma (LLC) cells were intravenously injected into wild type and myeloid p65 deficient (p65–/–) C57/BL6 mice. After 7 days, the mice were smoked for 7 days using the TE-10 smoking machine (3h, 300±15mg/m3 particles). Control groups were incubated with filtered air. At day 21, th…