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Characterization of miR-99a˜125b-2 polycistron in hematopoiesis and leukemogenesis

S Emmrich, K Henke, M Rasche, D Reinhardt, JH Klusmann · Klinische Pädiatrie · 2011 · Heft 05

Dokument
819649
CareLit-ID
Jahr
2011
Publikation
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Bibliografische Angaben

Zeitschrift
Klinische Pädiatrie
Autor:innen
S Emmrich, K Henke, M Rasche, D Reinhardt, JH Klusmann
Ausgabe
Heft 05 / 2011
Seiten
–
Erschienen: 2011-05-05 00:00:00
ISSN
0300-8630
DOI
10.1055/s-0031-1277090

Zusammenfassung

Introduction: We previously linked high expression of human chromosome 21 (hsa21) encoded miR-125b-2 to the increased risk of children with trisomy 21 (Down Syndrome; DS) to develop acute megakaryoblastic leukemia (DS-AMKL). MiR-125b-2 resides in a tricistronic miRNA cluster harboring miR-99a/let-7c/miR-125b-2. Methods: Here, we sought to decipher the combined and individual regulatory functions of miR-99˜125 cluster miRNAs during hematopoiesis and leukemic transformation by investigating lentivirally transduced human hematopoietic stem and progenitor cells. Results: TSS mapping of the miR-99˜125b polycistrons d…

Schlagworte

Klinische Pädiatrie