Sex-specific differences in adipose tissue lipolysis during body weight cycling
V Benz, M Bloch, A Foryst-Ludwig, C Böhm, R Winkler, S Wardat, L Herbst, K Giersch, P Wiedmer, J Spranger, U Kintscher · Diabetologie und Stoffwechsel · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Sex-specific differences in the regulation of body weight (BW) and adipose tissue (AT) distribution have been described recently. The underlying mechanisms are still largely unclear but point towards differences in AT metabolism. In a diet-induced obesity (DIO) mouse model we investigated sex-specific differences during BW cycling (reduction-maintenance-regain) and changes in AT lipolytic activity. Obesity was induced in C57BL/6J male (m) and female (f) mice (n=10 per group) by 15 weeks of high-fat diet (HFD) feeding (60% kcal from fat). Subsequently BW was reduced (-25%) by caloric restriction with a low-fat di…
