Brown adipose tissue (BAT) can normalize hyperglycemia and hypertriglyceridemia in mice

Aims: In adults, less than 1% of total adipose tissue is brown adipose tissue (BAT). It had been suggested, that BAT is only important for non shivering thermogenesis in newborn and rodents. A major role in the metabolism of adult humans was not supposed. However, based on recent studies using PET-CT, this had to be revised: After cold exposure, BAT was found in most of subjects investigated. A significant glucose uptake of several grams per day into BAT was measured. The aim of the present study was to further investigate the metabolic function of BAT. Methods: Mice with diet induced obesity (DIO) and mice with…