C57BL/6JRj mice are protected against diet induced obesity (DIO)

Aim: Due to genetic heterogeneity and various environmental factors influencing obesity, identifying susceptibility genes remains a big challenge. Experimental animal models offer a great opportunity to overcome these issues. Genetic and phenotypic differences among various mice substrains might provide insights into the genetic background of obesity. We determined the influence of different diets on epigonadal fat mass in two C57BL/6 mice substrains. Furthermore, we tested the hypothesis of genetic differences between both substrains. Methods: 16 healthy lean male mice of two different substrains C57BL/6NTac (T…