Effect of the high-fat diet on the clock gene expression in human monocytes

Aims: The circadian clock coordinates various behavioral and physiological processes including feeding behavior and energy metabolism. In turn, metabolic processes feed back onto the circadian clock as shown in recent studies of obesity and type 2 diabetes. Moreover, animal studies demonstrated alterations of behavioral and molecular circadian rhythms induced by the high-fat diet. However, there is little to no information about the effect of nutritional components on circadian mechanisms in humans. To address this, we investigated the influence of a high-fat isocaloric diet on daily expression profiles of clock…