Contrary changes in proliferative activity of the colonic epithelium during ageing and carcinogenesis
K Leiszter, O Galamb, F Sipos, T Krenács, S Spisák, G Veres, B Wichmann, K Tóth, G Valcz, ÁV Patai, A Kalmár, A Schöller, B Molnár, Z Tulassay · Zeitschrift für Gastroenterologie · 2011 · Heft 05
Bibliografische Angaben
Zusammenfassung
Background: Renewal of colonic mucosa takes 3–5 days. Increased epithelial proliferation and decreased apoptosis may result in gastrointestinal alterations like sporadic colorectal cancer (CRC). Changes in proliferative and apoptotic activity in human colonic epithelium during ageing are still unknown. Aims: Our aims were to determine and compare the mitotic index (MI) in healthy samples from children, adults and in colorectal adenoma-carcinoma-sequence (ACS). Our further aim was to identify proliferative genes with different mRNA expression in histologically intact children, adult and CRC samples. Materials and…
