The effect of aspartame consumption on body weight and ADH1, ADH4, ADH3 gene expression in mice

Introduction: Aspartame is widely used artificial sweetener. It may assist in weight management, prevention of dental caries, control of blood glucose of diabetics, and also can be used to replace sugar in foods. One of it's metabolite product is methanol which converts into formaldehyde due to alcohol dehydrogenase. Formaldehyde is a highly reactive small molecule containing active hydrogen atoms, which strongly bind to proteins and nucleic acids in form of adducts. Methods: CBA/CA mice were fed by table top sweetener aspartame with the maximum daily intake for 14 weeks, then in another experiment for 25 weeks.…