CareLit Fachartikel
The Role of PI3K p110gamma in chronic liver injury
K Dostert, M Saugspier, C Dorn, C Hellerbrand, E Gäbele · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
820349
CareLit-ID
Jahr
2012
Publikation
PDF
nein
Metadaten
DOI
ja
zitierfähig
Bibliografische Angaben
Zusammenfassung
Phosphatidyl-insitol–3-kinase (PI3K) is a central mediator in many signaling pathways, e.g. insulin signaling and in pro-inflammatory signaling via mTOR. Previous studies suggested a critical role of PI3K signaling during hepatic fibrogenesis, however, the role of different PI3K p110 isoforms has not been discriminated. The aim of this study was to assess the expression and function of the PI3K class 1B unit p110gamma in chronic liver disease. Methods and Results: Hepatic PI3K p110gamma Expression is increased in murine models of liver fibrosis as well as in patients with chronic liver diseases. In the bile duct…
Schlagworte
P110Gamma
Hepatic
Liver
Signaling
Expression
Fibrosis
Significantly
Fatty
Chronic
Fibrogenesis
Study
Class
Zeitschrift für Gastroenterologie
