CareLit Fachartikel
Nitric oxide supports carbon monoxide-induced protection from apoptosis in isolated primary mouse hepatocytes
J Schildgen, G Sass, H Schlueter, G Tiegs · Zeitschrift für Gastroenterologie · 2012 · Heft 01
Dokument
820353
CareLit-ID
Jahr
2012
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Zusammenfassung
Background and Aims: Heme oxygenase 1 (HO–1) induction or over-expression has been shown to interfere with acute and chronic hepatitis in mice. On the other hand, HO–1 is over-expressed in tumors and there interferes with apoptosis-induction via its product carbon monoxide (CO), inducing cytoprotective mechanisms in tumor cells. Our aim is to identify signaling pathways and mediators of CO-induced cytoprotection as specific targets for tumor therapy. Methods: Freshly isolated primary mouse hepatocytes (PH) were incubated in the presence of the CO donor methylene chloride (MC) for 2 to 6 hours. Nitric oxide (NO)…
Schlagworte
CO
HO-1
NO
cytoprotection
Tumor
Apoptosis
Chloride
Actinomycin
Hepatitis
Zeitschrift für Gastroenterologie
